19 June 2025

How to achieve your dissolution goals with USP 4?

The flow-through cell dissolution method was initially developed for compounds that are poorly soluble. However, its flexibility allows for many other applications. We explore this topic in greater detail in a new application note.

The solubility and permeability of an active pharmaceutical ingredient (API) are of major importance, as they determine whether the API can dissolve, pass cell membranes, and become bioavailable. But what about controlled hydrodynamics, flexible media volume, pH change, or apparent dissolution?

The flow-through cell dissolution technique has consistently met the needs of researchers seeking an exploratory, informative, yet robust and compromised method of drug release. The next milestone in this adventure may be your current dosage form project. Whether you are dealing with APIs, modified release tablets, semi-solids, long acting injectables, medical devices: any conventional or complex dosage form, the flow-through cell dissolution technique may still surprise you.

Read our recently published comprehensive application note to learn more about the flow-through cell dissolution technique.